Pharmacokinetics

Pharmacokinetics: single dose

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Learn how to calculate the key pharmacokinetic properties of a drug and understand the importance of each in relation to drug dose and plasma concentration.

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Learning outcomes

Calculate the bioavailability and volume of distribution of pharmaceutical drugs in different contexts.
Determine half-lives and elimination constants for a variety of pharmaceutical drugs.
Identify when steady state is reached and how to calculate it.
Design graphs to enable estimation and calculation of pharmacological half-lives.

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Skills

Concepts, Principles and Theories

What is meant by absorption and bioavailability
What is the volume of distribution
What factors contribute to the elimination of a drug from the body
What is the difference between zero order and first order elimination kinetics
What is meant by the elimination half-life, elimination constant and total clearance
What is meant by the steady state and therapeutic window

Manipulating and Presenting Data

How to calculate the bioavailability when the IV and non-IV dose are the same and when the doses are different
How to calculate the volume of distribution and total clearance
How to calculate steady state for a single dose and multiple doses
How to calculate the dose interval for a dosage regimen
How to calculate the loading dose and maintenance dose
How to graphically estimate the initial plasma concentration and rate

Interpreting and Analysing Data

How to estimate the volume of distribution from a graph
How to calculate steady-state concentration
How to analyse graphs to estimate the drug's half-life
How to analyse a graph's trendline to calculate pharmacokinetic parameters

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Prof. Nicky King

University of Exeter

"The great thing about Smart Worksheets is that they tell you at every point whether you’ve got it right or wrong, what might be wrong and how you might go about changing it. The students found that really valuable. In their exam, we found that the average mark in the maths questions rose from 59% to 79%, which made a really big difference to the student outcome.”

Details

Degrees

Biomedical science

Pharmacological science

Biochemistry

Biological science

Modules

Pharmacology

Topic

Pharmacokinetics

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