Pharmacokinetics

Competitive antagonism

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Analyse organ bath experimental data to quantify drug effects, construct dose-response and Schild plots for drug characterisation, and identify and resolve issues in data visualisation.

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Learning outcomes

Calculate FBC, normalised response %, dose ratio and logarithmic values using organ bath experimental data.
Construct dose-response curves and Schild plots.
Interpret dose-response graphs and Schild plots and associated data to investigate a drug of interest.
Troubleshoot errors in dose-response data visualisation.

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Skills

Manipulating and Presenting Data

How to calculate and determine drug concentrations
How to calculate and record the normalised response %
How to calculate the dose ratios for each antagonist

Interpreting and Analysing Data

How to correctly plot a dose-response curve
How to identify the type of physiological response being measured
How to determine maximum response from plots
How to analyse the effect of the antagonist
How to identify errors in dose-response curves and remedies for error
How to determine gradient for Schild plot

Concepts, Principles and Theories

How to abbreviate maximum response and concentration at which half-maximal response is achieved

Designing and Planning Experiments

How to select independent and dependent variables for experimental set up

Obtaining and Recording Data

How to record histamine concentrations and volumes for experiment

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University of Exeter

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Details

Degrees

Pharmacological science

Biochemistry

Modules

Pharmacology

Topic

Pharmacokinetics

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